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The Content Was Refreshed: 20 Apr 2019 | 19:23:57

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From fasting to weight lifting, celebrity trainer Matt Roberts reveals how to transform your fitness – and your life
Posted: April 14, 2019, 3:48 pm
Retirement isn’t about giving up on life, it’s about embracing a new chapter. Here’s how to make the most of it…
Posted: April 14, 2019, 3:48 pm
Stress and anxiety at work is a killer — but these tips can help you tackle the negative feelings the 9 to 5 can bring
Posted: April 14, 2019, 3:48 pm
The Duchess of Sussex is considering a 'natural' home birth but mums who have been through it are divided on the issue
Posted: April 14, 2019, 3:48 pm
PMID:  Artif Cells Nanomed Biotechnol. 2018 ;46(sup3):S931-S942. Epub 2018 Oct 11. PMID: 30307334Abstract Title:  The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis.Abstract:  BACKGROUND: Combinations of natural products with low toxicities using tumor-targeting carriers may improve cancer treatment. The combined parthenolide and ginsenoside compound K (CK) within tLyp-1 liposomes, with the aim of improving the efficacy of lung cancer treatment.RESULTS: In vitro studies in A549 human pulmonary adenocarcinoma cells demonstrated that parthenolide/CK tLyp-1 liposomes increased reactive oxygen species levels and induced mitochondrial apoptosis. It enters into cells via receptor-mediated uptake and micropinocytosis, followed by endosomal/lysosomal escape. In vivo studies illustrated that it produced a greater antitumor effect than combined administration of these compounds, with minimal toxicity.CONCLUSION: The findings of this study indicated that combined application of natural products in nanocarriers could offer attractive therapeutic options.

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Posted: April 14, 2019, 3:15 pm
PMID:  Pathol Oncol Res. 2019 Apr 1. Epub 2019 Apr 1. PMID: 30937835Abstract Title:  Phloretin Inhibits the Human Prostate Cancer Cells Through the Generation of Reactive Oxygen Species.Abstract:  Phloretin is a flavonoid with known anticancer activities. However, we do not fully understand how phloretin mitigates prostate cancer on the molecular level. In the present study, we examined changes in proliferation, colony formation, and migration after phloretin treatment in human prostate cancer cells PC3 and DU145. We measured reactive oxygen species (ROS) and gene expression. Phloretin increased ROS and suppressed cell proliferation, migration, and colony formation in both cell lines. Additionally, phloretin treatment increased oxidative stress, as demonstrated through lower antioxidant enzymes (catalase, SOD2, Gpx1, Gpx3). In addition, their regulator CISD2 decreased in expression. We also found that increased ROS significantly downregulated multiple components of the Wnt/β-catenin signaling pathway (β-catenin, TCF4, FoxA2, c-Myc) and Twist1. Thus, anticancer activity of phloretin against human prostate cancer cells occurs through generating ROS to influence Wnt/β-catenin signaling. The results of this study suggest that phloretin has a therapeutic effect on prostate cancer in vitro, inhibiting the proliferation and migration of cancer cell lines PC3 and DU145. The mechanism of phloretin appears to be increasing ROS production. We thus recommend phloretin as a promising anticancer therapeutic agent.

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Posted: April 14, 2019, 3:15 pm
PMID:  Vet World. 2018 Nov ;11(10):1433-1439. Epub 2018 Oct 17. PMID: 30532498Abstract Title:  Supplementation of whole grain flaxseeds () along with high cholesterol diet and its effect on hyperlipidemia and initiated atherosclerosis in Wistar albino male rats.Abstract:  Background and Aim: Flaxseeds are known to have varying antihypercholesterolemic and antiatherogenic activity due to its lignan secoisolariciresinol diglucoside, alpha-linolenic acid, and omega-3 fatty acids. The beneficial effect of whole grain dietary flaxseed was evaluated experimentally in high cholesterol diet (HCD)-fed Wistar albino rats.Materials and Methods: Male Wistar albino rats (200 g) were divided into four groups of 12 rats each. Group I rats kept as control and given basal rat chew diet, Group II as positive control for induction of hypercholesterolemia and atherosclerosis by addition of 1% cholesterol and 15% saturated edible oil to the 1000 g of standard rat chew diet (HCD), Group III rats fed with whole grain flaxseed powder at 7.5 g/kg of rat/day in the standard rat chew diet and kept as flaxseed control, and Group IV rats supplemented with flaxseed at 7.5 g/kg of rat/day along with HCD and maintained for 90 days.Results: Group II rats revealed significantly (p

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Posted: April 14, 2019, 3:15 pm
PMID:  Prostaglandins Other Lipid Mediat. 2019 Apr 5. Epub 2019 Apr 5. PMID: 30959179Abstract Title:  Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer.Abstract:  Cervical cancer is the second leading cause of cancer death in women in India. Previously, we have reported that alpha linolenic acid (ALA), induced apoptosis in cervical cancer cell lines and reduced expression of E6 and E7 oncoproteins with simultaneous decrease in Cox2/VEGF/MAP kinase proteins. Here, we investigated the tumor retardation potential of flax oil (FO), rich in ALA, in mouse papilloma model. Flax oil significantly reduced tumor volume and weight in mice compared to the Tumor control (TC) group. Interestingly, compared to cisplatin (Cis) alone, there was slightly enhanced decrease in tumor weight when FO was given together with Cis (Cis + FO). A significant increase in plasma antioxidant levels in mice; and increase in lipid peroxidation in tumor with simultaneous decrease in liver tissues was observed in Cis + FO group compared to either TC or Cis groups. FO and Cis + FO significantly modulated immune response in miceby increasing CD8α and IFNγ and decrease in IL-4 expression. Interestingly, when given together with cisplatin, flax oil significantly reduced HPV E6 and E7 oncoprotein expression with concomitant increase in the relative mRNA expression of tumor suppressor genes p53 and Rb. Thus, flax oil couldbe explored for its therapeutic potential in cervical cancer.

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Posted: April 14, 2019, 3:15 pm
PMID:  Food Chem Toxicol. 2019 Mar 21 ;127:188-196. Epub 2019 Mar 21. PMID: 30905866Abstract Title:  Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells.Abstract:  Significant evidence indicated that flaxseed (Linum usitatissimum) possesses various positive health aspects such as reducing the risk of cancer and cardiovascular diseases. The fatty acids are considered to be responsible for these benefits of flaxseed. Herein, the in vitro effects of flaxseed extract on the growth and apoptosis of human breast cancer MCF-7 cells were investigated. The MCF-7 cells treated with flaxseed extract showed a dose-dependent decrease in cell viability. The flaxseed extract induced reactive oxygen species and the flow cytometric analysis demonstrated that flaxseed fatty acids triggered apoptosis of MCF-7 cells, which wasalso shown by the loss of mitochondrial membrane potential and caspase cascade reaction. Thus, the flaxseed extract regulated the growth of MCF-7 cells and induced apoptosis. Eventually, the flaxseed could be used as a dietary supplement to prevent breast cancer.

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Posted: April 14, 2019, 3:15 pm
PMID:  Psychopharmacology (Berl). 2019 Jan 4. Epub 2019 Jan 4. PMID: 30607481Abstract Title:  Pterostilbene, an active component of the dragon's blood extract, acts as an antidepressant in adult rats.Abstract:  BACKGROUND: Hippocampal neurogenesis has been widely considered as one of the potential biological mechanisms for the treatment of depression caused by chronic stress. Many natural products have been reported to be beneficial for neurogenesis.OBJECTIVES: The present study is designed to investigate the effect of dragon's blood extract (DBE) and its biologically active compound, pterostilbene (PTE), on hippocampal neurogenesis.METHODS: The male Sprague-Dawley (SD) rats were used in this study, which were maintained on the normal, DBE and PTE diet groups for 4 weeks before dissection in the normal rat model and behavioral testing in the CUS depression rat model. Meanwhile, DMI-treated rats are subcutaneously injected with DMI (10 mg/kg, i.p.).RESULTS: Results revealed that DBE and PTE have the ability to promote hippocampal neurogenesis. DBE and PTE also promoted the proliferation of neural stem cells isolated from the brain of suckling rats. Oral administration of DBE and PTE induced the proliferation, migration, and differentiation of neural progenitor cells (NPCs) in chronic unexpected stressed (CUS) model rats, and improved the behavioral ability and alleviated depress-like symptoms of CUS rats. It was also observed that PTE treatment significantly induced the expression of neurogenesis-related factors, including BDNF, pERK, and pCREB.CONCLUSION: Oral administration of PTE could affect neurogenesis and it is likely to be achieved via BDNF/ERK/CREB-associated signaling pathways.

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Posted: April 14, 2019, 3:15 pm
PMID:  Res Pharm Sci. 2019 Feb ;14(1):55-63. PMID: 30936933Abstract Title:  Pterostilbene increases Fas expression in T-lymphoblastic leukemia cell lines.Abstract:  Treatment of acute lymphoblastic leukemia (ALL) has been promising in last decades, but side effects still persist and searching for the least toxic agents continue. Pterostilbene (PTE) is a natural compound with several anti-cancer and anti-oxidant properties. Fas, as a member of death inducing family of tumor necrosis factor (TNF) receptors with an intracellular death domain, can initiate the extrinsic apoptosis signaling pathway. Here after the half maximal inhibitory concentration (IC) determination in cell lines, we searched for PTE effects on Fas, both in mRNA and surface levels in two ALL cell lines, Jurkat and Molt-4. After harvesting cells in optimum situations, MTS assay was used to determine ICconcentrations. Real-time polymerase chain reaction (RT-PCR) and flow cytometry were performed for Fas mRNA and surface expression variations after exposure to PTE. The findings showed that PTE decreases cell viability with different extent in two ALL cell lines. In addition to inducing apoptosis, it can increase Fas in both gene and cell surface expression in the same concentrations. Pterostilbene as a natural anti-cancer agent can increase Fas expression both in mRNA and surface levels that results in apoptosis signal transduction improvement which sensitizes cells to apoptosis by immune effector cells. As a result, abnormal cells removal would be more efficiently with the minimum side effects on normal cells.

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Posted: April 14, 2019, 3:15 pm
PMID:  Neurochem Res. 2019 Jan 28. Epub 2019 Jan 28. PMID: 30689162Abstract Title:  Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests.Abstract:  Pterostilbene (PTE), a natural dimethylated analog of resveratrol, possesses numerous health-beneficial properties. The ability of PTE to cross the blood-brain barrier raised the possibility that this compound may modulate central nervous system functions, including seizure activity. The aim of our study was to investigate the activity of PTE in the larval zebrafish pentylenetetrazole (PTZ) seizure assay and three acute seizure tests in mice, i.e., in the maximal electroshock seizure threshold (MEST), 6 Hz-induced psychomotor seizure threshold and intravenous (iv) PTZ tests. Additionally, potential antidepressant activity of PTE was estimated in the forced swim test in mice. The chimney test was used to determine the influence of PTE on motor coordination in mice, while its influence on neuromuscular strength was assessed in the grip strength test in mice. Locomotor activity was determined to verify the results from the forced swim test. PTE revealed an evident anticonvulsant effect both in zebrafish larvae (10 µM; 2 h-incubation) and mice (at doses of 100 and 200 mg/kg, intraperitoneally) but it did not exhibit antidepressant potential in the forced swim test. Furthermore, it did not cause any statistically significant changes in motor coordination, neuromuscular strength and locomotor activity in mice. In conclusion, our present findings demonstrate for the first time the anticonvulsant potential of PTE. The aforementioned results suggest that it might be employed in epilepsy treatment, however, further precise studies are required to verify its activity in other experimental seizure and epilepsy models and its precise mechanism of action should be determined.

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Posted: April 14, 2019, 3:15 pm
PMID:  J Tradit Complement Med. 2019 Apr ;9(2):138-142. Epub 2018 May 3. PMID: 30963048Abstract Title:  Clinical study of effectiveness and safety of CELcomplexcontaining Cucurbita Pepo Seed extract and Flax and Casuarina on stress urinary incontinence in women.Abstract:  Aim: The safety and effectiveness of a preparation containing a mix of Cucurbita Pepo Seed extract, Equisetum arvense and Linum usitatissimum - Flax A (CELcomplex) on stress urinary incontinence (SUI) was evaluated in female patients recruited from 20 urological and gynaecological outpatient clinics in Slovakia.Methods: A total of 86 women aged from 32 to 88 with SUI (grade 1 = 44, grade 2 = 42) were enrolled in the study and followed-up for six weeks (point 1) and twelve weeks (point 2). The primary outcome of the study was evaluated by changes in day-time and nocturnal urinary frequency (bathroom visits) and urinary incontinence episodes (leaks). Also, adverse events were quantified as well as the self-perceived effectiveness of the treatment. Research Ethics Board approval was obtained for this study.Results: After 12 weeks of treatment there was a 30% (grade 1 SUI, p 

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Posted: April 14, 2019, 3:15 pm
PMID:  Food Sci Biotechnol. 2019 Apr ;28(2):491-499. Epub 2018 Sep 27. PMID: 30956861Abstract Title:  Antioxidant and immune-enhancing effects of probiotic200655 isolated from kimchi.Abstract:  Probiotic properties including antioxidant and immune-enhancing effects of200655 isolated from kimchi were evaluated. The tolerance of three strains (200655,KCTC 3108, andGG to bile salts (0.3% oxgall, 24 h) was similar, and200655 showed the highest tolerance to gastric juice (0.3% pepsin, 3 h). All strains presented similar autoaggregation ability.200655 showed higher cell surface hydrophobicity and adhesion ability on HT-29 cells.200655 did not produceβ-glucuronidase and was sensitive to ampicillin, tetracycline, chloramphenicol, and doxycycline. Additionally,200655 showed the highest antioxidant effects in DPPH and ABTS radical scavenging, andβ-carotene bleaching assays. RAW 264.7 cells treated with200655 produced more nitric oxide, induced nitric oxide synthase, and cytokine related to immune-enhancing effects such as interleukin-1β and interleukin-6. Therefore,200655 could be useful as a probiotic strain for older people.

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Posted: April 14, 2019, 3:15 pm
NPR's Sacha Pfeiffer speaks with Dr. Paul Offit, director of the Vaccine Education Center at the Children's Hospital of Philadelphia, about the last time the U.S. mandated measles vaccinations.
Posted: April 14, 2019, 2:50 pm
Software that can replace doctors for certain tasks has a big responsibility. The Food and Drug Administration is now figuring out how to determine when computer algorithms are safe and effective.
Posted: April 14, 2019, 2:50 pm
HEALTH-EBOLA/

Here's a look at how the latest outbreak of the Ebola virus in Congo become the second-deadliest in history, claiming 772 lives since last August. 

Posted: April 14, 2019, 2:25 pm
Liver and kidney transplant surgery

When Harry Cayton started looking into the dysfunction at the College of Dental Surgeons of B.C., he discovered something alarming, and the problem persisted even after a major shift in leadership.

Posted: April 14, 2019, 2:25 pm
elias and sajia

A doctor at Massachusetts General Hospital has written a letter to the American embassy in Halifax, urging an expedited visa for Sajia Yaqobi, whose son needs cancer treatment in Boston.

Posted: April 14, 2019, 2:25 pm
No vaping sign

Health Canada has asked Canadians for 'advice' on ways to prevent vaping from becoming 'normalized among young people.' Meanwhile, one tobacco giant reports an increase in 'poly-usage,' as new vaping products put it 'back in a growth industry.'

Posted: April 14, 2019, 2:25 pm
Fisher-Price Sleeper-Recall

Fisher-Price has recalled nearly five million infant sleepers in the U.S. after more than 30 babies died in them over a 10-year period. Health Canada said Saturday that the Fisher Price Rock 'N Play Sleeper is "not permitted for sale in Canada."

Posted: April 14, 2019, 2:24 pm
Organ transplant recipients Kristen Wheaton-Clayton and Donnie Ritchie

Two New Brunswickers who both received life-saving transplants have different views on proposed Nova Scotia legislation that would require adults to opt out of organ donation if they don't want to be donors when they die.

Posted: April 14, 2019, 2:24 pm
dogs kitsilano beach vancouver summer sun weather

A new study suggests that the Echinococcus multilocularis tapeworm that was initially confined to Western Canada has now spread to southern Ontario, posing a risk to dogs and their owners.

Posted: April 14, 2019, 2:24 pm
organ donation

Members at Province House unanimously passed the Human Organ and Tissue Donation Act Friday, a bill that will require people to opt out if they do not want to be an organ donor. The bill still needs to be proclaimed and that's expected to take up to 18 months.

Posted: April 14, 2019, 2:24 pm
Opioid overdose

A new kind of overdose is showing up among Vancouver drug users and it’s scaring front-line workers who are trying to save fentanyl users who are using substances adulterated with bizarre and dangerous fillers.

Posted: April 14, 2019, 2:24 pm
The Content Was Refreshed: 20 Apr 2019 | 19:23:57

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