China’s top legislature will consider tougher rules on research involving human genes and embryos, the first such move since a Chinese scientist sparked controversy last year by announcing he had made the world’s first “gene-edited” babies.
The Health-Care Survivor
There was no relief from grieving my brother – until I realised an important lesson
When my older brother Jerry became ill with Aids in the 1980s, he was working as a psychologist in New York and I was living in a small cottage in Berkeley, California, with the man who is now my husband. I would phone Jerry every evening and fly in once a month to help him clean his apartment and stock up on food, as well as to discuss his treatments with his doctors and HIV researchers. On one occasion, while he was recovering from a parasitic infection that had caused lesions in his brain and given him dementia, he took my hand and said to me: “I’d be orphaned if it weren’t for you.”
Like hundreds of thousands of other brothers and sisters across the world, I kept telling Jerry: “Just hang on, because one day soon there’s going to be a cure.”
What can you do when you fear someone you know may be considering suicide? It can feel daunting, but suicide prevention experts say we all can help someone at risk by reaching out and showing we care.
(Image credit: Maria Fabrizio for NPR)
PMID: Carcinogenesis. 2019 Mar 12 ;40(1):93-101. PMID: 30418550 Abstract Title: Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells. Abstract: Polyphenols have shown promising bioactivity in experimental in vitro and in vivo models for cancer chemoprevention. However, consumed orally, they are often transformed by gut microbes into new active principles with so far incompletely deciphered molecular mechanisms. Here, enterolacton, S-equol and urolithin A as representatives of metabolites of lignans, isoflavones and ellagitannins, respectively, were examined for their impact on HCT116 colon cancer cell growth, cooperativity with oxaliplatin and p53 dependency in vitro. Read More
PMID: Obesity (Silver Spring). 2019 Apr ;27(4):612-620. Epub 2019 Feb 15. PMID: 30768775 Abstract Title: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis. Abstract: OBJECTIVE: Urolithin A (UroA) is a major metabolite of ellagic acid produced following microbial catabolism in the gut. Emerging evidence has suggested that UroA modulates energy metabolism in various cells. However, UroA's physiological functions related to obesity and insulin resistance remain unclear.METHODS: Male mice were intraperitoneally administrated either UroA or dimethyl sulfoxide (vehicle) along with a high-fat diet for 12 weeks. Read More