Serrapeptase And The Power Of Enzymes

Enzymes are catalysts, made from amino acids by RNA (Ribonucleic Acid), which is produced by DNA (Deoxyribonucleic Acid); essential need a specific temperature and pH (the measure of acidity/alkalinity) to perform their work. Enzymes from plants work best at the human body’s temperature and pH. They are essential in every function of growth, repair and therefore the health of every living cell in the body.

Thousands of enzymes are working every second to build and regenerate the body. They are continually being converted or produced, and they depend upon proper living nutrition to keep ahead of daily damage and degeneration. They do need help in this job, and this essential help comes from co-enzymes. These are critical vitamins and minerals such as Vitamin B12. Even a small deficiency in B12 results in disease. This becomes such a problem with elderly people, on poor diets, that they at times need injections.

Another co-enzyme, zinc, is needed by about 80 enzyme activities, not to mention the famous co-enzyme Q10. Without enzymes and coenzymes, there would be no living thing. All living things depend upon enzymes to sustain growth and health.

Three Types Of Enzymes

Food/Digestive Enzymes – These take the basic building blocks delivered by the food we eat and convert it to colloidal particles (the smallest particles that exist in a free state) that can be turned into healthy living tissue.

Metabolic Enzymes – Metabolic enzymes use colloids to keep all of our organs and tissues functioning with hundreds of diverse chemical activities, repairing organs and fighting disease. The body’s ability to stay healthy, to repair tissue when injured, to protect us from disease, is directly related to the quality and number of enzymes, coenzymes and nutritious food.

Clean-Up Enzymes – This third type is not really a separate group, but they are the enzymes for the last job on the line, clearing up. They are responsible for eliminating the mess, left in the body from the construction and repair work that is in continuous operation. These clean-up enzymes clear our bodies of the undigested carbohydrates, proteins and any non-vital tissue floating around. Another vital job is to provide anti-inflammatory enzymes to fight infections and tissue damage.

Enzymes Do Specific Jobs, Including
  • Digesting food
  • Breaking down toxins
  • Cleansing the blood
  • Supporting the immune system
  • Converting protein into muscle
  • Contracting muscles
  • Eliminating carbon dioxide from the lungs
  • Supporting the pancreas and other vital organs

Enzymes are the workers in the body – they carry out every chemical reaction. To have a healthy body, you need both workers (enzymes) and building materials. The building materials are proteins (amino acids), minerals, and vitamins. All of these are necessary to build a healthy body. Trying to function without all the essential enzymes is the reason for most body malfunctions.

Seven Categories Of Food Enzymes
  • Lipase to break down fat;
  • Protease to breakdown protein
  • Cellulase to break down fibres
  • Amylase to break down starch
  • Lactase to break down dairy foods
  • Sucrase to breakdown sugars
  • Maltase to breakdown grain
The Inflammatory Response

The inflammatory response is usually an essential mechanism for protecting the body from attack by invading organisms, damaged cells and trauma. When the immune system becomes dysfunctional, it loses its ability to differentiate between innocuous and potentially dangerous substances. This dysfunction results in a wide array of autoimmune diseases such as rheumatoid arthritis, ulcerative colitis, allergies, psoriasis, uveitis, multiple sclerosis and some forms of cancer.

In spite of the vast range of successful enzyme studies showing safety and effectiveness, the standard therapy for inflammatory-mediated diseases and trauma include drugs such as steroids and non-steroidal anti-inflammatory agents (NSAIDs). These classes of drugs, in most cases, do offer temporary, symptomatic relief from swelling, inflammation and accompanying pain, but without treating the underlying condition.

Non-steroidal Anti-inflammatory Drugs (NSAIDs) And Their Side Effects

The drugs used to control the inflammatory response may be immunosuppressive and cause dangerous side effects. The benefits and long-term risks associated with the use of NSAIDs, especially in cases of rheumatoid arthritis; need to be weighed very carefully. If not successfully treated, the inflammatory process itself can lead to limitation of joint function and destruction of bone, cartilage and articular structures.

NSAIDs are one of the most widely prescribed drugs for rheumatoid arthritis and other inflammatory joint conditions. They inhibit the biosynthesis of prostaglandins by irreversibly blocking cyclooxygenase, the enzyme which catalyses the reactions of arachidonic acid to endoperoxide compounds.

The neurological and gastrointestinal side effects of these agents have been reviewed in considerable detail. All of the NSAIDs, except Cytotec, inhibit prostaglandin El, a local hormone responsible for gastric mucosal cytoprotection. A common side effect of these medications is gastric ulcers. Adverse reactions that are more serious such as blood dyscrasias, kidney damage and cardiovascular effects have been noted. Most physicians rotate among the ten most widely prescribed NSAIDs, as soon as one causes side effects or stops working.

Introducing Serrapeptase, The ‘Miracle’ Enzyme

The search for a superior enzyme that offers safe but powerful anti-inflammatory properties, thus averting the terrible side effects, ended when Serratia peptidase (Serrapeptase) enzyme was discovered in the early 1970′s. Serrapeptase is now in extensive clinical use throughout Europe and Asia as a viable alternative to salicylates, ibuprofen (sold as an OTC in the USA.) and the more potent NSAIDs. Serrapeptase is an anti-inflammatory, proteolytic enzyme isolated from the micro-organism, Serratia E15 and has no inhibitory effects on prostaglandins, is devoid of gastrointestinal side effects and offers a sensible alternative.

What Does Serrapeptase Do?

Serrapeptase is processed commercially in the laboratory through fermentation. It was initially found in the silkworm where it is naturally present in its intestine. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatory effects of this naturally occurring enzyme. The silkworm has a special relationship with the Serratia E15 micro-organisms in its intestines. The enzymes secreted by the bacteria in silkworm intestines can dissolve avital tissue but have no detrimental effect on the host’s living cells. Thus by dissolving the silkworm’s protective cocoon (avital tissue), the winged creature is able to emerge and fly away.

The mechanisms of action of Serrapeptase, at the sites of various inflammatory processes, consist fundamentally of a reduction of the exudative phenomena and an inhibition of the release of the inflammatory mediators. This peptidase induces fragmentation of fibrinous aggregates and reduces the viscosity of exudates, thus facilitating drainage of these products of the inflammatory response and thereby promoting the tissue repair process. Studies suggest that Serrapeptase has a modulatory effect on specific acute phase proteins that are involved in the inflammatory process. This is substantiated by a report of significant reductions in C3 and C4 complement, increases in opsonising protein and decreases in concentrations of haptoglobin, which is a scavenger protein that inhibits the lysosomal protease.

Enteric Coating For Intestinal Absorption

Several research groups have reported the intestinal absorption of Serrapeptase. Serrapeptase is well absorbed orally when formulated with an enteric coating. It is known that proteases and peptidases are only absorbed in the intestinal area.

These enzymes are mobilised directly to the blood and are not easily detectable in urine. Other enzymes with structural similarities have been reported to be absorbed through the intestinal tract. Chymotrypsin is transported into the blood from the intestinal lumen. Horseradish peroxidase can cross the mucosal barrier of the intestine in a biologically and immunologically active form. Several studies have appeared so far which refer to the systemic effects of orally given proteases and peptidases (e.g. Serrapeptase), such as repression of oedema and suppression of blood vessel permeability induced by histamine or bradykinin. These enzymes also affect the kallikrein-kinin system and the complement system, thus modifying the inflammatory response.

Superior Effects

In vitro and in vivo studies reveal that Serrapeptase has a specific, anti-inflammatory effect, superior to that of other proteolytic enzymes. A review of the scientific literature, including a series of controlled, clinical trials with large patient groups, suggests that Serrapeptase is useful for a broad range of inflammatory conditions. If one considers the fact that anti-inflammatory agents are among the most widely prescribed drugs, the use of a safe, proteolytic enzyme such as Serrapeptase would be a welcome addition to the physician’s armamentarium of physiologic agents

Serrapeptase Has A Wide Range of Applications

The discovery of this unique biological phenomenon led researchers to study clinical applications of the Serrapeptase enzyme in man.

Researchers in Germany have used Serrapeptase for atherosclerosis to digest atherosclerotic plaque without harming the healthy cells lining the arterial wall. Today, researchers consider atherosclerosis an inflammatory condition (similar to many other degenerative diseases whose cause is identified as chronic inflammation). Some immunologists are even categorising atherosclerosis as a benign tumour. Hardening and narrowing of the arterial wall is a cumulative result of microscopic trauma; inflammation occurs in the presence of oxidised lipids. Serrapeptase does not interfere with the synthesis of cholesterol in the body, but acts as an anti-inflammatory and helps clear avital tissue from the arterial wall. It is important to note that cholesterol in its pure state is an antioxidant and a necessary component of the major organ and hormonal systems in the body. The use of medications, which block cholesterol biosynthesis, may eventually damage the liver and compromise the antioxidant status of the eyes, lungs and other soft tissues.

Powerful Anti-inflammatory

In addition to atherosclerosis, there is a growing list of conditions, which respond to Serrapeptase taken orally in tablet or capsule form.
Pain Of Any Kinds

  • Arthritis
  • Multiple Sclerosis
  • Rheumatoid Arthritis
  • Headaches and Migraines (Caused by Inflammation)
Lung Problems
  • Emphysema
  • Bronchitis
  • Pulmonary Tuberculosis
  • Bronchial Asthma
  • Bronchiectasis
Eye Problems
  • Inflammation
  • Blocked Veins etc
ENT Problems
  • Sinusitis
  • Chronic Ear Infections
  • Runny Nose etc
  • Sports Injuries
  • Traumatic Swelling
  • Post Operative
  • Leg Ulcers (that are not healing)
Inflammation Of Any Kind
  • Inflammatory Bowel (Chron’s, colitis etc.)
  • Cystitis
  • Fibromyalgia
  • Breast Engorgement
  • Fibrocystic Breast
  • Varicose Veins etc
  • Varicose Veins etc
  • Cardiovascular Disease

Please note: This list is not definitive, and it does not constitute advice of any kind.

Thanks to Robert Redfern of Naturally Healthy Publications, for original information.


My Serrapeptase Adventure is the remarkable story of “The ‘Miracle’ Enzyme”, Serrapeptase, which gave me back my life in January 2006. It goes on to chart the four life-changing years in which I learnt that many of the symptoms from which Serrapeptase has rescued me were, in fact, known, and even expected, side effects of the toxic cocktail of prescription medications, which I took before I knew about Serrapeptase and to which I have never needed to return.

Mike Tawse

More Information

The ‘Miracle’ Enzyme is Serrapeptase – The 2nd Gift from Silkworms (by Robert Redfern) is a remarkable book about a remarkable enzyme. Read in detail, the fascinating studies, uses and practitioner’s reports about Serrapeptase.

Serrapeptase Information Website

Serrapeptase Newsletters

  • Kee WH. Tan SL, Lee V. Salmon YM. The treatment of breast engorgement with Serrapeptase: a randomised double blind controlled trial. Singapore Med J. 1989:30(1): 48-54.
  • Mizukoshi, D. et al. A double blind clinical study of Serrapeptase in the treatment of chronic sinusitis. Igaku Ayrni 109:50-62.1979.
  • Carratu, L. et al. Physio-chemical and rheological research on mucolytic activity of Serrapeptase in chronic broncho-pneumopathies. Curr. Ther. Res. 28(6): 937-951. 1980.
  • Braga, P.C. et al. Effects of Serrapeptase on muco-ciliary clearance in patients with chronic bronchitis. Curr. Ther. Res. 29(5): 738-744,1981.
  • Mazzonie, A. et al. Evaluation of Serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind randomised trial versus placebo. J. Int. Med. Res. 18(5): 379-388,1990.
  • Kakinumu, A. et al. Regression of fibrinolysis in scalded rats by administration of Serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.
  • Marly, M. Enzymotherapie anti-inflammatoire a l’aide de la Serrapeptase: resultats cliniques en traumatologie et en ORL. C RTherapeut. 3:9-19,1985.
  • Odagiri, J. et al. Clinical applications of Serrapeptase in sinusitis. Med. Consult. New Remedy 6:201-209, 1979.
  • Yamazaki, J. et al. Anti-inflammatory activity of Serrapeptase, a protease produced by a strain of Serratia. Folia Pharmacol. Japon. 6^302-314,1967.
  • Harad, Y. Clinical efficacy of Serrapeptase on buccal swelling after radical operation for chronic sinusitis. Igaku Ayumi 123:768-778.1982.
  • Matsudo, A. et at. Effect of Serrapeptase on inflammatory oedema following operation for thyropid disease. Med. Consult. New Remedy 18:171-175, 1981.
  • Fujitani, T. et al. Effect of anti-inflammatory agent on transfer of antibiotics to the maxillary sinus mucosa in chronic sinusitis. Otorhinolaryngol. Clin. North Am. 66:557-565. 1976.
  • Tago. T. and Mitsui, S. Effects of Serrapeptase in dissolution of sputum, especially in patients with bronchial asthma. Jap. Clin. Exp. Med. 49:222-228, 1972.
  • Mazzonie, A. et al. Evaluation of Serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind randomised trial versus placebo. J. int. Med. Res. 18(5): 379-388,1990.
  • Kase, Y. et al. A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, Serrapeptase and seaprose. Arzneimittelforschung 32:374-378,1982.
  • Marriott, C. Modification of the rheoloaical properties of mucus by drugs. Adv. Exp. Med. Biol. 144^75-84, 1982.
  • Majima. Y. et al. Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am. Rev. Respit. Dis. 141:79-83.1990.
  • Miyata, K. Intestinal absorption of Serrapeptase. J ApplBiochem. 1980:2:111-16.
  • Aso T. et al. Breast engorgement and its treatment: Clinical effects of (Serrapeptase) an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynaecology (Japanese). 1981:33:371-9.
  • Esch PM, Gemgross H. Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joints in treatment with Serrapeptase a prospective study (German). FortschrMed. 1989; 107(4): 67-8, 71-2.
  • Majima Y, lnagaki M, Hirata K. Takeuchi K, M orishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988; 244(6):355-9.
  • Selan L, Berlutti F, Passariello C. Comodi-Ballanti MR, Thaller MC. Proteolytic enzymes: a new treatment strategy for prosthetic infections? Antimicrob Agents Cheroother. 1993; 37(12): 2618-21.
  • Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T, et al. Augmentation by Serrapeptase of tissue permeation by cefotiam (Japanese). Jpn JAntibiot. 1986; 39(3): 761-71.

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