What Is Serrapeptase?

Serrapeptase is processed commercially in the laboratory through fermentation. It was initially found in the silkworm where it is naturally present in its intestine. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatory effects of this naturally occurring enzyme. The silkworm has a special relationship with the Serratia E15 micro-organisms in its intestines. The enzymes secreted by the bacteria in silkworm intestines can dissolve avital tissue but have no detrimental effect on the host’s living cells. Thus by dissolving the silkworm’s protective cocoon (avital tissue), the winged creature is able to emerge and fly away.

What Does Serrapeptase Do?

The mechanisms of action of Serrapeptase, at the sites of various inflammatory processes, consist fundamentally of a reduction of the exudative phenomena and an inhibition of the release of the inflammatory mediators. This peptidase induces fragmentation of fibrinous aggregates and reduces the viscosity of exudates, thus facilitating drainage of these products of the inflammatory response and thereby promoting the tissue repair process. Studies suggest that Serrapeptase has a modulatory effect on specific acute phase proteins that are involved in the inflammatory process. This is substantiated by a report of significant reductions in C3 and C4 complement, increases in opsonising protein and decreases in concentrations of haptoglobin, which is a scavenger protein that inhibits the lysosomal protease.

Enteric Coating For Intestinal Absorption

Several research groups have reported the intestinal absorption of Serrapeptase. Serrapeptase is well absorbed orally when formulated with an enteric coating. It is known that proteases and peptidases are only absorbed in the intestinal area.

These enzymes are mobilised directly to the blood and are not easily detectable in urine. Other enzymes with structural similarities have been reported to be absorbed through the intestinal tract. Chymotrypsin is transported into the blood from the intestinal lumen. Horseradish peroxidase can cross the mucosal barrier of the intestine in a biologically and immunologically active form. Several studies have appeared so far which refer to the systemic effects of orally given proteases and peptidases (e.g. Serrapeptase), such as repression of oedema and suppression of blood vessel permeability induced by histamine or bradykinin. These enzymes also affect the kallikrein-kinin system and the complement system, thus modifying the inflammatory response.

Superior Effects

In vitro and in vivo studies reveal that Serrapeptase has a specific, anti-inflammatory effect, superior to that of other proteolytic enzymes. A review of the scientific literature, including a series of controlled, clinical trials with large patient groups, suggests that Serrapeptase is useful for a broad range of inflammatory conditions. If one considers the fact that anti-inflammatory agents are among the most widely prescribed drugs, the use of a safe, proteolytic enzyme such as Serrapeptase would be a welcome addition to the physician’s armamentarium of physiologic agents

Serrapeptase Has A Wide Range of Applications

The discovery of this unique biological phenomenon led researchers to study clinical applications of the Serrapeptase enzyme in man.

Researchers in Germany have used Serrapeptase for atherosclerosis to digest atherosclerotic plaque without harming the healthy cells lining the arterial wall. Today, researchers consider atherosclerosis an inflammatory condition (similar to many other degenerative diseases whose cause is identified as chronic inflammation). Some immunologists are even categorising atherosclerosis as a benign tumour. Hardening and narrowing of the arterial wall is a cumulative result of microscopic trauma; inflammation occurs in the presence of oxidised lipids. Serrapeptase does not interfere with the synthesis of cholesterol in the body, but acts as an anti-inflammatory and helps clear avital tissue from the arterial wall. It is important to note that cholesterol in its pure state is an antioxidant and a necessary component of the major organ and hormonal systems in the body. The use of medications, which block cholesterol biosynthesis, may eventually damage the liver and compromise the antioxidant status of the eyes, lungs and other soft tissues.

Powerful Anti-Inflammatory

In addition to atherosclerosis, there is a growing list of conditions, which respond to Serrapeptase taken orally in tablet or capsule form.

Pain Of Any Kinds
  • Arthritis
  • Multiple Sclerosis
  • Rheumatoid Arthritis
  • Headaches and Migraines (Caused by Inflammation)
Lung Problems
  • Emphysema
  • Bronchitis
  • Pulmonary Tuberculosis
  • Bronchial Asthma
  • Bronchiectasis
Eye Problems
  • Inflammation
  • Blocked Veins etc
ENT Problems
  • Sinusitis
  • Chronic Ear Infections
  • Runny Nose etc
  • Sports Injuries
  • Traumatic Swelling
  • Post Operative
  • Leg Ulcers (that are not healing)
Inflammation Of Any Kind
  • Inflammatory Bowel (Chron’s colitis etc.)
  • Cystitis
  • Fibromyalgia
  • Breast Engorgement
  • Fibrocystic Breast
  • Varicose Veins etc
  • Varicose Veins etc
  • Cardiovascular Disease

Please note: This list is not definitive, and it does not constitute advice of any kind.

Thanks to Robert Redfern of Naturally Healthy Publications, for original information.

Serrapeptase References


My Serrapeptase Adventure is the remarkable story of “The ‘Miracle’ Enzyme”, Serrapeptase, which gave me back my life in January 2006. It goes on to chart the four life-changing years in which I learnt that many of the symptoms from which Serrapeptase has rescued me were, in fact, known, and even expected, side effects of the toxic cocktail of prescription medications, which I took before I knew about Serrapeptase and to which I have never needed to return.

Mike Tawse


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